Can bring the spiders back to life Little horn Plants bombs, shoots killable shots, tries to put Isaac in holes in the floor, can teleport Chub Charges at isaac and spawns leeches Gurdy Spawns enemies and shoots in the direction of the player Mega maw Shoots moving purple fire and spawns hopper Mega fatty Jumps around at isaac, spawns enemies and can suck the player closer before releasing a cascade of shots CHAD Spawns bomb flies and charges at the player, gets smaller and faster when damaged The hollow Bounces around the room, over gaps and rocks diagonally The husk Bounces around quickly and spawns spiders Dark one Makes the room dark and shoots lasers Polycephalus Hides under the ground and spawns enemies and shoots in all directions sometimes Carrion queen Spawns damaging poop and charges at isaac, can only be damaged on the back The wretch Jumps at Isaac, putting down slowing creep and spawning spiders Gurdy Jr Shoots in all directions and charges at isaac, bouncing off walls Peep Jumps around, puts down damaging creep, eyes go pop out and bounce around dealing contact damage as the fight goes on Pestilence Horseman, shoots exploding shots leaving damaging creep, spawns flies, loses head halfway through, the same except spawns spiders The frail Exactly like pin until killed, gains all health back, gets faster and shoots lasers and splitting shots The stain Moves underground, pops up, spawns leeches, puts down creep, or shoots all round itself in a hard to dodge move The foresaken Flies around until it spawns a skeleton and becomes invincible until its killed. Sticks top the wall and shoots blood shots and brimstone The duke of flies Bounces around the room and spawns flies Famine Horseman, charges to the side and spawns flies, loses head in second phase and shoots triple shots Rag man Spawns Phsycic spiders and shoots homing shots. You can still damage and kill him, but even if he escapes, the fight ends and Isaac wins the battle.Blighted ovum Two separate parts, large one charges and small one shoots brimstone, only the large one can be hit Fistula Splits into two smaller ones when killed, repeats until the part dies and spawns a leech The haunt Must fight three ghosts before the boss can be fought. When Hornfel's health is low enough (Around 50 or so), his minecart will be destroyed, and he will try to escape through one of the many doors.

Objects such as fires, barrels and nitro barrels will sometimes pass through in a minecart.

Several enemies can be seen riding on the Minecarts during the fight that can attack Isaac, such as Blasters, Quakeys, Gurgles and Dannys. Send a fake Hornfel in a cart instead of Hornfel, and hitting this dummy will spawn several troll bombs. After doing so a few times, he gets sick and vomits a fireball that will release fire in the cardinal (+) directions. Go faster and faster on a single track while throwing regular bombs. Pull out three black mines with red blinking parts and throw them around the arena, that will fire brimstone beams in the cardinal directions (+) after some time. (Can be: regular bombs, Hot Bombs, Sad Bombs and Stone Bombs) When he enters the room with the mine cart again, he can: Hornfel rides around in a minecart going in and out boss doors.

He has a huge horn growing out of his forehead. Hornfel is a small red monster that can be found in the mines.

The binding of isaac antibirth mines